These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
    Author: Smith DL, Robertson HT, Desmond RA, Nagy TR, Allison DB.
    Journal: Int J Obes (Lond); 2011 May; 35(5):652-7. PubMed ID: 21079617.
    Abstract:
    OBJECTIVE: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor. RESULTS AND CONCLUSION: Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared with controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate.
    [Abstract] [Full Text] [Related] [New Search]