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  • Title: A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment.
    Author: Chiu YL, Chen SA, Chen JH, Chen KJ, Chen HL, Sung HW.
    Journal: ACS Nano; 2010 Dec 28; 4(12):7467-74. PubMed ID: 21082810.
    Abstract:
    A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.
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