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  • Title: Use of microelectrodes for electrochemiluminescent detection in microfluidic devices.
    Author: Fredrick SJ, Gross EM.
    Journal: Bioanalysis; 2009 Apr; 1(1):31-6. PubMed ID: 21083185.
    Abstract:
    Microfluidic devices allow for fast detection with little reagent consumption. They also offer portability and the ability to mimic biological systems. Currently, many microfluidic devices are a hybrid of the microchip components, such as flow channels and wells, and larger instrumentation. There is a need to develop miniaturized detectors for lab-on-a-chip applications. Electrochemical detection methods have the advantage of ease of miniaturization. The electrochemical method, electrochemiluminescence, has the potential to be miniaturized and incorporated into a lab-on-a-chip device. As in other electrochemical methods, electrochemiluminescence is straightforward to miniaturize, but also possesses the sensitivity of a fluorescence detection method. In our laboratory, we have been developing carbon ink microelectrodes as the working electrode for a miniaturized electrochemiluminescence system. Since the signal is proportional to the electrode area, the challenge has been to maximize the signal-to-noise ratio and maintain low detection limits as the electrode size decreases.
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