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  • Title: [Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities].
    Author: Iagoda AV, Gladkikh NN.
    Journal: Ter Arkh; 2010; 82(9):49-53. PubMed ID: 21086621.
    Abstract:
    AIM: To reveal changes in the thromboxane-prostacyclin balance and platelet aggregability in patients with various variants of minor cardiac abnormalities. SUBJECTS AND METHODS: Six-five patients (mean age 23.0 +/- 0.7 years) with minor cardiac abnormalities and 10 apparently healthy individuals were examined. Platelet aggregation induced by adrenaline, adenosine diphosphate, collagen) and the plasma levels of thromboxane B2 (TxB) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) were determined. RESULTS: Patients with abnormally located chordae (ALC) were found to have no deviations in the thromboxane-prostacyclin balance and platelet aggregability. Only decreased collagen aggregation was recorded in the groups of first-degree mitral prolapse (MP) and first-degree MP + ALC; in second-degree MP and second-degree MP + ALC, there was a reduction in platelet aggregation on all inductors and an increase in TxB2. Patients with myxomatous degeneration of the mitral valve exhibited reduced collagen-induced platelet aggregation and lower plasma 6-keto-PGF1alpha levels. CONCLUSION: The most pronounced changes in the thromboxane-prostacyclin balance and platelet aggregability were found in patients with MP and second-degree regurgitation, three intracardiac micro-abnormalities, and myxomatous degeneration of the mitral valve.
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