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  • Title: Antitumor and immunomodulatory activity of arabinoxylans: a major constituent of wheat bran.
    Author: Cao L, Liu X, Qian T, Sun G, Guo Y, Chang F, Zhou S, Sun X.
    Journal: Int J Biol Macromol; 2011 Jan 01; 48(1):160-4. PubMed ID: 21087621.
    Abstract:
    We aimed to investigate the antitumor activity of wheat bran arabinoxylans, including the role of its immunostimulatory effect. In S180 tumor-bearing mice arabinoxylan administration significantly inhibited the growth of mouse transplantable tumors and remarkably promoted thymus and spleen indexes, splenocyte proliferation, natural killer cell and macrophage phagocytosis activity, interleukin 2 production, and delayed-type hypersensitivity reaction. In addition, it increased peripheral leukocyte count, and bone-marrow cellularity in tumor-bearing mice. As the antitumor activity of arabinoxylans may be mediated via the improvement in the immune response, they can be considered an antitumor agent with immunomodulatory activity.
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