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  • Title: N-acetyl cysteine protects TMJ chondrocytes from oxidative stress.
    Author: Ueno T, Yamada M, Sugita Y, Ogawa T.
    Journal: J Dent Res; 2011 Mar; 90(3):353-9. PubMed ID: 21088145.
    Abstract:
    Temporomandibular joint (TMJ) inflammation is closely associated with oxidative stress. This study tested the potential of N-acetyl cysteine (NAC), an anti-oxidant amino-acid derivative, in alleviating oxidative stress-related damage in TMJ chondrocytes. The inflammatory condition was simulated by the addition of hydrogen peroxide (H₂O₂) to TMJ-derived chondrocyte cultures. Exposure to H₂O₂ decreased the cell population by half within 2 days as a result of induced apoptosis and reduced proliferation. Gene expression of aggrecan and collagen II, as well as glycosaminoglycan production, were reduced by more than 70%. These compromised chondrocyte viability and function were fully restored by the addition of NAC to the cultures. NAC reduced the H₂O₂-elevated intracellular reactive oxygen species to the normal level and increased cellular glutathione reserves. These results indicate that NAC restores oxidative stress-induced cell death and severe functional impairment in TMJ chondrocytes, and warrant in vivo testing to explore its therapeutic potential as an anti-inflammatory agent.
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