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  • Title: Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template.
    Author: Helmig S, Rotaru A, Arian D, Kovbasyuk L, Arnbjerg J, Ogilby PR, Kjems J, Mokhir A, Besenbacher F, Gothelf KV.
    Journal: ACS Nano; 2010 Dec 28; 4(12):7475-80. PubMed ID: 21090671.
    Abstract:
    DNA origami, the folding of a long single-stranded DNA sequence (scaffold strand) by hundreds of short synthetic oligonucleotides (staple strands) into parallel aligned helices, is a highly efficient method to form advanced self-assembled DNA-architectures. Since molecules and various materials can be conjugated to each of the short staple strands, the origami method offers a unique possibility of arranging molecules and materials in well-defined positions on a structured surface. Here we combine the action of light with AFM and DNA nanostructures to study the production of singlet oxygen from a single photosensitizer molecule conjugated to a selected DNA origami staple strand on an origami structure. We demonstrate a distance-dependent oxidation of organic moieties incorporated in specific positions on DNA origami by singlet oxygen produced from a single photosensitizer located at the center of each origami.
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