These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of lacidipine pre-treatment on diabetic neuropathy in rats.
    Author: Singh J, Aditya S, Lal H, Arora B.
    Journal: Arch Physiol Biochem; 2011 Feb; 117(1):12-7. PubMed ID: 21091185.
    Abstract:
    OBJECTIVE: The present study was planned to evaluate the effects of lacidipine on STZ induced diabetic neuropathy. MATERIAL AND METHODS: Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, motor nerve conduction velocity (MNCV), nociception and histopathology of tibial nerve. Forty rats were divided in to four groups of 10 each. Group I: Control (vehicle). Group II: STZ (50mg/kg, iv, single injection). Group III: Lacidipine (0.5 mg/kg, po, daily + STZ). Group IV: STZ + insulin (4 unit/kg, sc, bid). Similar protocol was used for other parameters also. RESULTS: Lacidipine pre-treatment failed to reduce blood sugar levels in diabetic rats but prevented deterioration of motor nerve conduction velocity as compared to STZ diabetic rats. Hyperalgesia induced by STZ was antagonized by lacidipine. Histology of nerve showed less structural damage in lacidipine pre-treated group. DISCUSSION AND CONCLUSION: Thus, lacidipine prevents the development of neuropathic changes induced by STZ in rats.
    [Abstract] [Full Text] [Related] [New Search]