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  • Title: Reversible graft versus host reaction as cause of erythrophagic splenomegaly in a child?
    Author: Beck JD, Weinig JE, Müller-Hermelink HK, Lemmel EM.
    Journal: Eur J Pediatr; 1977 Oct 12; 126(3):175-84. PubMed ID: 21093.
    Abstract:
    The case history of a 9 months old infant with hepatosplenomegaly, pancytopnaenia and disturbances of clotting and cellular immune reactivity is reported. The spleen was removed and showed striking erythrophagocytosis by proliferating histiocytes, typical of "familial erythrophagocytic reticulosis" (Farquhar). A graft-versus-host reaction is discussed as a possible underlying cause. The favourable clinical course and full recovery point to an interrelation with primary hypersplenism.
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