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  • Title: Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.
    Author: Liu KG, Robichaud AJ, Greenfield AA, Lo JR, Grosanu C, Mattes JF, Cai Y, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter LE, Comery TA.
    Journal: Bioorg Med Chem; 2011 Jan 01; 19(1):650-62. PubMed ID: 21093272.
    Abstract:
    As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT(6) antagonists. The synthesis and detailed SAR of this class of compounds are reported.
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