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  • Title: Can the early elimination of calcineurin inhibitors result in clinical benefits?
    Author: Weir MR.
    Journal: Transplant Proc; 2010 Nov; 42(9 Suppl):S16-20. PubMed ID: 21095444.
    Abstract:
    Ideally, every kidney should serve its owner for his or her remaining life expectancy. Current approaches with immunosuppression have steadily reduced early rejection rates. However, we have not seen a comparable improvement in graft longevity. Reduction of acute rejection rates should improve survival, unless concurrent nephrotoxicity offsets this benefit. An important question is whether selective substitution of other drugs/biologicals for calcineurin inhibitors will permit adequate immunoprophylaxis, yet improve graft longevity.
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