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  • Title: An integrated, low noise patch-clamp amplifier for biological nanopore applications.
    Author: Wang G, Dunbar WB.
    Journal: Annu Int Conf IEEE Eng Med Biol Soc; 2010; 2010():2718-21. PubMed ID: 21096207.
    Abstract:
    We present an integrated, low noise patch-clamp amplifier for biological nanopore applications. Our amplifier consists of an integrator-differentiator architecture coupled with a novel opamp design in the CMOS 0.35 µm process. The post-layout full-chip simulation shows the input referred noise of the amplifier is 0.49 pA RMS over a 5 kHz bandwidth using a verified electrical model for the biological nanopore system. In our biological nanopore experiments studying protein-DNA interactions, we encounter capacitive transients with a nominal settling time of 5 ms. Our amplifier design reduces the settling time to 0.2 ms, without requiring any compensation circuitry.
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