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  • Title: Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog.
    Author: Irokawa D, Ota M, Yamamoto S, Shibukawa Y, Yamada S.
    Journal: Dent Mater J; 2010 Nov; 29(6):721-30. PubMed ID: 21099164.
    Abstract:
    The aim of this study was to investigate the effect of β tricalcium phosphate (β-TCP) particle size on recombinant human platelet-derived growth factor-BB (rhPDGF-BB)-induced regeneration of periodontal tissue in dog. The control group (rhPDGF-BB alone) was characterized by incomplete, newly formed bone. The large-particle β-TCP (L-TCP(O))/rhPDGF-BB group showed a statistically significant increase in both new bone and cementum formation compared to the small-particle β-TCP (S-TCP(G))/rhPDGF-BB group. These findings suggest that L-TCP(O)-particle promotes rhPDGF-BB-induced formation of bone and cementum.
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