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  • Title: Catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines by phase-transfer catalyzed alkylations.
    Author: Shirakawa S, Liu K, Ito H, Maruoka K.
    Journal: Chem Commun (Camb); 2011 Feb 07; 47(5):1515-7. PubMed ID: 21103466.
    Abstract:
    Efficient catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines has been achieved via asymmetric alkylation of 1-cyanotetrahydro-β-carbolines using a binaphthyl-modified N-spiro-type chiral phase-transfer catalyst. This is a valuable example of hitherto difficult highly enantioselective alkylations at α-carbon of the cyano group under phase-transfer conditions.
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