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  • Title: Aptamer-based turn-on fluorescent four-branched quaternary ammonium pyrazine probe for selective thrombin detection.
    Author: Yan S, Huang R, Zhou Y, Zhang M, Deng M, Wang X, Weng X, Zhou X.
    Journal: Chem Commun (Camb); 2011 Jan 28; 47(4):1273-5. PubMed ID: 21103494.
    Abstract:
    In this thrombin detection system, the bright fluorescence of TASPI is almost eliminated by the DNA aptamer TBA (turn-off); however, in the presence of thrombin, it specifically binds to TBA by folding unrestricted TBA into an anti-parallel G-quadruplex structure and then releasing TASPI molecules, resulting in vivid and facile fluorescence recovery (turn-on).
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