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  • Title: The role of protein synthesis in polymorphonuclear leukocyte phagocytosis II.
    Author: Kasprisin DO, Harris MB.
    Journal: Exp Hematol; 1978 Aug; 6(7):585-9. PubMed ID: 211044.
    Abstract:
    Polymorphonuclear leukocytes collected from healthy human volunteers were treated with puromycin which inhibited protein synthesis in the cell. The neutrophils exhibited a marked decrease in phagocytosis after 1 h. The myeloperoxidase mediated conversion of iodide to a protein-bound form was also decreased. Hexosemonophosphate shunt activity remained similar for both puromycin treated PMN and control cells at 1 h. The results suggest that new protein synthesis is necessary to maintain PMN function at full capacity.
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