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  • Title: Treatment of severe fungal keratitis with subconjunctival amphotericin B.
    Author: Carrasco MA, Genesoni G.
    Journal: Cornea; 2011 May; 30(5):608-11. PubMed ID: 21107247.
    Abstract:
    PURPOSE: To report the beneficial properties of subconjunctival amphotericin B as an adjunctive therapy in patients with severe fungal keratitis. METHODS: Case reports and review of medical literature. Four patients with advanced fungal keratitis were treated with repeated injections of subconjunctival amphotericin B in addition to topical and systemic antifungal treatment. RESULTS: Two to 8 injections were given to each patient. All patients showed rapid clinical improvement after the injections. No serious adverse effects were observed. However, all patients experienced pain during the injections. CONCLUSIONS: Subconjunctival injections of amphotericin B are useful as an adjunctive treatment of advanced fungal keratitis. This treatment assures compliance and may be an alternative to avoid a surgical intervention in an acute stage of advanced fungal keratitis. More cases are needed to validate our findings.
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