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  • Title: Stability-indicating TLC-densitometric method for estimation of dexrabeprazole and domperidone in pharmaceutical dosage form.
    Author: Chitlange SS, Mulla AI, Pawbake GR, Wankhede SB.
    Journal: Prep Biochem Biotechnol; 2010; 40(4):337-46. PubMed ID: 21108137.
    Abstract:
    A stability-indicating thin layer chromatographic (TLC) method for determination of dexrabeprazole (DEX) and domperidone (DOM) in combined dosage form has been developed and validated. The mobile phase selected was acetone:toluene:methanol (4.5:4.5:0.5, v/v/v) with ultraviolet (UV) detection at 285 nm. The retention factors for DEX and DOM were found to be 0.49 ± 0.02 and 0.24 ± 0.03, respectively. The method was validated with respect to linearity, accuracy, precision, and robustness. The linearity range for DEX was 50-350 ng/band (r² = .9960) and for DOM was 100-700-n /band (r² = .9982), respectively. The method was successfully applied for the analysis of drugs in pharmaceutical formulation.
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