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  • Title: The effect of hypercapnia and hypertension on cerebral oxygen balance during one-lung ventilation for lung surgery during propofol anesthesia.
    Author: Iwata M, Inoue S, Kawaguchi M, Kimura M, Tojo T, Taniguchi S, Furuya H.
    Journal: J Clin Anesth; 2010 Dec; 22(8):608-13. PubMed ID: 21109133.
    Abstract:
    STUDY OBJECTIVE: To investigate whether jugular bulb venous oxygen saturation (SjO(2)) values increased with induced hypercapnia or induced hypertension during propofol-based anesthesia for one-lung ventilation (OLV). DESIGN: Prospective clinical study. SETTING: Operating room at University hospital. PARTICIPANTS: 15 adult patients scheduled for elective thoracic procedures in the lateral position. INTERVENTIONS: General anesthesia was maintained with propofol combined with epidural anesthesia. During OLV, hypercapnia (PaCO(2) = 50 mmHg) and hypertension (20% increase in mean arterial pressure) were applied. MEASUREMENTS: SjO2 values were measured. MAIN RESULTS: With hypercapnia, SjO(2) values increased 30 ± 18% (from 54.3 ± 8.8% to 69.3 ± 6.3%). With hypertension, SjO(2) values were increased by 9 ± 18% (from 54.4 ± 9.0% to 58.5 ± 8.8%). These changes were significantly different. No significant differences regarding SaO(2) were observed during OLV in the experimental period. CONCLUSION: Hypercapnia, not hypertension, significantly improved cerebral oxygen balance without observed side effects during propofol anesthesia.
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