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  • Title: Effects of fenoldopam mesylate infusion on splanchnic perfusion after myocardial revascularization on cardiopulmonary bypass: an ultrasound Doppler study.
    Author: Meco M, Allaz MC, Cirri S.
    Journal: J Cardiothorac Vasc Anesth; 2011 Aug; 25(4):642-6. PubMed ID: 21109463.
    Abstract:
    OBJECTIVES: To measure the effects of fenoldopam mesylate infusion on splanchnic blood flow in patients undergoing myocardial revascularization with cardiopulmonary bypass. DESIGN: An experimental observational study. SETTING: A single-institution community hospital. PARTICIPANTS: Eighteen patients undergoing on-pump coronary artery bypass graft surgery. INTERVENTIONS: Fenoldopam mesylate infusion (0.1 μg/kg/min). MEASUREMENTS AND MAIN RESULTS: Blood flow through the celiac artery, superior mesenteric artery, portal vein and hepatic artery were assessed by means of Doppler measurements. The main hemodynamic variables were measured using echocardiography. The infusion of fenoldopam significantly increased the blood flow through both celiac and superior mesenteric arteries by decreasing vascular resistance. The percentage of cardiac output directed to these 2 vessels increased significantly; the increase through the superior mesenteric artery was greater compared with the celiac artery. Portal vein and hepatic artery blood flow also consistently increased. No significant variations were observed with respect to hemodynamic variables. CONCLUSIONS: The infusion of fenoldopam increased the flow through the celiac artery and superior mesenteric artery; the effect was higher for the latter. These changes did not affect the hemodynamic variables.
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