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  • Title: Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.
    Author: Lam PY, Yan CW, Chiu PY, Leung HY, Ko KM.
    Journal: Fitoterapia; 2011 Apr; 82(3):393-400. PubMed ID: 21111034.
    Abstract:
    Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin.
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