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  • Title: Prenylated C6-C3 compounds with molecular diversity from the roots of Illicium oligandrum.
    Author: Ma SG, Tang WZ, Liu YX, Hu YC, Yu SS, Zhang Y, Chen XG, Qu J, Ren JH, Liu YB, Xu S, Liu J, Liu YY, Li Y, Lü HN, Wu XF.
    Journal: Phytochemistry; 2011 Jan; 72(1):115-25. PubMed ID: 21112063.
    Abstract:
    Eleven prenylated C(6)-C(3) compounds, illioliganpyranone A (1), illioliganfunone A-D (2-5), and illioliganone D-I (6-11), together with five known prenylated C(6)-C(3) compounds (12-16), were isolated from roots of Illicium oligandrum. The structures of 1-11 were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, and CD experiments. Possible biosynthetic pathways to compounds 1-16 derived from a common precursor of 5-allylbenzene-1,2,4-triol were postulated. All compounds were evaluated for cytotoxic activities against five human cancer cell lines (HCT-8, Bel-7402, BGC-823, A549 and A2780). Compound 15 exhibited significant cytotoxicity against HCT-8, BGC-823, A549, and A2780 cell lines with IC(50) values of 0.30-2.57 μM. Compound 16 showed moderate selective cytotoxicity against sensitive A2780 cells with IC(50) value of 1.38 μM.
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