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  • Title: Duloxetine-related tardive dystonia and tardive dyskinesia: a case report.
    Author: Chen PY, Lin PY, Tien SC, Chang YY, Lee Y.
    Journal: Gen Hosp Psychiatry; 2010; 32(6):646.e9-646.e11. PubMed ID: 21112461.
    Abstract:
    Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics and sometimes antidepressants or calcium channel blockers. Duloxetine-related tardive syndrome is rarely reported in the literature. We report one case of tardive dystonia and tardive dyskinesia occurring in a 58-year-old female with major depressive disorder, who developed distressing oral dyskinesia, mandibular dystonia with trismus and dystonia over left neck after treatment of duloxetine (30-60 mg per day) for 18 months. Despite discontinuation of duloxetine, she only obtained partial remission. Even though this association has been rarely reported, duloxetine may pose a potential risk of inducing tardive syndrome. Clinicians should cautiously detect early signs of movement abnormality when prescribing antidepressants.
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