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  • Title: Nonspecific effect of m7GMP on protein-RNA interactions.
    Author: Sonenberg N, Shatkin AJ.
    Journal: J Biol Chem; 1978 Oct 10; 253(19):6630-2. PubMed ID: 211125.
    Abstract:
    Cap analogs m7GMP and m7GDP inhibit binding of eukaryotic initiation factors to reovirus capped mRNA but also inhibit complex formation involving uncapped mRNA or 18 S rRNA. Furthermore, Escherichia coli DNA-dependent RNA polymerase binds 18 S rRNA and this interaction is also blocked by m7GMP. These results indicate that inhibition by cap analogs is not a stringent test for putative cap-specific binding between proteins and mRNA.
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