These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A multiple primary carcinoma consisting of leukoplakia and SCC: a case report with p53 mutation analysis.
    Author: Hassan NM, Tada M, Shindoh M, Hamada J, Kashiwazaki H, Shimo T, Ashikaga Y, Yamazaki Y, Sasaki A, Moriuchi T, Inoue N.
    Journal: Anticancer Res; 2010 Nov; 30(11):4773-8. PubMed ID: 21115940.
    Abstract:
    Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of the three leukoplakias. One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). This case showed that individual oral tumours may have different genetic changes even when they develop in a single patient. Therefore, this report provided strong evidence that in cases of multiple tumours it is necessary to design tailor-made therapies for each individual tumour rather than a single standardised therapy for all multiple tumours.
    [Abstract] [Full Text] [Related] [New Search]