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Title: Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins. Author: Hong L, Simon JD. Journal: Metallomics; 2011 Mar; 3(3):262-6. PubMed ID: 21116546. Abstract: This review examines recent studies on the thermodynamics of copper association with amyloid-β, α-synuclein and prion protein, with an eye towards using this information to understand the etiology of associated neurodegenerative diseases. A variety of binding affinities and binding sites, which are essential to understand the function and consequence of copper-protein interaction, have been reported for copper to these three neurobiologic systems. This current review reconciles the disparate models presented in the literature.[Abstract] [Full Text] [Related] [New Search]