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  • Title: Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells.
    Author: Lee JK, Jung JS, Park SH, Park SH, Sim YB, Kim SM, Ha TS, Suh HW.
    Journal: Arch Pharm Res; 2010 Nov; 33(11):1843-50. PubMed ID: 21116788.
    Abstract:
    Visnagin, which is found in Ammi visnaga, has biological activity as a vasodilator and reduces blood pressure by inhibiting calcium influx into the cell. The present study demonstrates the anti-inflammatory effect of visnagin on lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. When cells were treated with visnagin prior to LPS stimulation, production of nitric oxide and expression of iNOS were attenuated in a dose-dependent manner. Visnagin also caused a significant decrease of mRNA expression and release of TNF-α, IL-1β and IFNγ. In addition, visnagin reduced LPS-induced IL-6 and MCP-1 mRNA level. We further found that visnagin dose-dependently inhibited LPS-induced AP-1 and NF-κB luciferase activities. Taken together, our results for the first time suggest that the anti-inflammatory effect of visnagin might result from the inhibition of transcription factors, such as AP-1 and NF-κB.
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