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  • Title: Characterization of nanoparticles by matrix assisted laser desorption ionization time-of-flight mass spectrometry.
    Author: Ramalinga U, Clogston JD, Patri AK, Simpson JT.
    Journal: Methods Mol Biol; 2011; 697():53-61. PubMed ID: 21116953.
    Abstract:
    Determining the molecular weight of nanoparticles can be challenging. The molecular weight characterization of dendrimers, for example, with varying covalent and noncovalent modifications is critical to their use as therapeutics. As such, we describe in this chapter a protocol for the analysis of these molecules by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).
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