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  • Title: Influence of different distal nerve degeneration period on peripheral nerve collateral sprouts regeneration.
    Author: Kou Y, Zhang P, Yin X, Wei S, Wang Y, Zhang H, Jiang B.
    Journal: Artif Cells Blood Substit Immobil Biotechnol; 2011 Aug; 39(4):223-7. PubMed ID: 21117869.
    Abstract:
    The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomized common peroneal and chronically denervated TIB nerve stumps. There was a remarkable decreasing of the regenerated myelinated axons number after the distal nerve suffered 8 weeks deterioration, suggesting that short-term denervation did not affect the collateral sprouts regeneration but more prolonged denervation profoundly reduced collateral sprouts regenerated in the distal nerve stump.
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