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  • Title: Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function.
    Author: Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, Earnshaw WC, Ruchaud S.
    Journal: Biochem Soc Trans; 2010 Dec; 38(6):1655-9. PubMed ID: 21118143.
    Abstract:
    The CPC [chromosomal passenger complex; INCENP (inner centromere protein), Aurora B kinase, survivin and borealin] is implicated in many mitotic processes. In the present paper we describe how we generated DT40 conditional-knockout cell lines for incenp1 and survivin1 to better understand the role of these CPC subunits in the control of Aurora B kinase activity. These lines enabled us to reassess current knowledge of survivin function and to show that INCENP acts as a rheostat for Aurora B activity.
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