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  • Title: Hemophagocytic syndrome in a child with severe Crohn's disease and familial Mediterranean fever.
    Author: Uslu N, Demir H, Balta G, Saltik-Temizel IN, Ozen H, Gürakan F, Yüce A.
    Journal: J Crohns Colitis; 2010 Sep; 4(3):341-4. PubMed ID: 21122524.
    Abstract:
    Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially fatal, severe condition of hyperinflammation caused by the uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. Here we report a fatal hemophagocytic syndrome in a 11-year-old boy with a diagnosis of both Crohn's disease receiving immunosuppressive therapy and familial Mediterranean fever. It is important to evaluate the patients with inflammatory bowel disease receiving immunosuppressive therapy presenting with unexplained fever, cytopenia, progression of organomegaly and biochemical changes for the investigation of HLH for diagnosis and treatment.
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