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  • Title: Transcriptional regulation of Foxp3 in regulatory T cells.
    Author: Haiqi H, Yong Z, Yi L.
    Journal: Immunobiology; 2011 Jun; 216(6):678-85. PubMed ID: 21122941.
    Abstract:
    Regulatory T (Treg) cells constitute a unique T-cell lineage that plays a pivotal role in the maintenance of the peripheral tolerance. The transcription factor Foxp3 (Forkhead box P3) was identified as a master regulator for the development and function of Treg cells. It is well defined that Foxp3 expression is critical to program CD4+CD25+ Treg cell development and function; however, the molecular mechanisms that are involved in the regulation of the Foxp3 expression remain unclear. Recent studies have showed an indication that this process is influenced by a number of transcription factors. In this review, we summarize the current knowledge of how Foxp3 expression is controlled at molecular level by focusing on these factors.
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