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  • Title: Copper catalysis in the construction of indole and benzo[b]furan rings.
    Author: Cacchi S, Fabrizi G, Goggiamani A.
    Journal: Org Biomol Chem; 2011 Feb 07; 9(3):641-52. PubMed ID: 21125122.
    Abstract:
    This perspective reports on some of the main copper-catalyzed routes to the construction of the pyrrole and furan rings incorporated into the indole and benzo[b]furan systems, respectively. The first part illustrates the synthesis of indoles through cyclizations of 2-alkynylanilid(n)es, preformed or generated in situ, and cyclizations via intramolecular N-arylation, N-vinylation, and C-C bond forming reactions. The second part illustrates the synthesis of benzo[b]furans through cyclizations of preformed 2-alkynylphenols, domino synthesis of 2-alkynylphenols/cyclization processes, and cyclizations via intramolecular O-arylation reactions.
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