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  • Title: [Splenic granulomas - rare extraintestinal manifestation of Crohn's disease].
    Author: Schulz C, von Arnim U, Kuester D, Fischbach F, Malfertheiner P.
    Journal: Z Gastroenterol; 2010 Dec; 48(12):1367-70. PubMed ID: 21125512.
    Abstract:
    Extraintestinal manifestations of inflammatory bowel disease occur frequently in parallel to the inflammation in the bowel. The activity of extraintestinal manifestations is often divergent to the activity of intestinal inflammation. We here present the case of a rare extraintestinal manifestation of Crohn's disease and report on a 52-year-old patient with known Crohn's disease and primary sclerosing cholangitis (PSC) in clinical remission. Multiple lesions of the spleen were observed in routine MR tomography. The histological examination of a specimen obtained by MR-guided fine needle biopsy showed non-caseating epitheloid cell granulomas. The splenic granulomas regressed completely and spontaneously without specific immunmodulatory therapy.
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