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  • Title: Synthesis and anticonvulsant activity of some alkanamide derivatives.
    Author: Tarikogullari AH, Kilic FS, Erol K, Pabuccuoglu V.
    Journal: Arzneimittelforschung; 2010; 60(10):593-8. PubMed ID: 21125808.
    Abstract:
    A group of N-phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at omega position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(2,6-dimethylphenyl)acetamide.
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