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  • Title: [Renal malakoplakia: an underestimate cause of renal failure].
    Author: Daroux M, Frimat M, Mirault T, Fleury D, Lemaitre V, Noel LH, Vanhille P.
    Journal: Nephrol Ther; 2011 Apr; 7(2):111-6. PubMed ID: 21126934.
    Abstract:
    Malakoplakia is an inflammatory granulomatous disease induced by defective phagocytic activity of macrophage. Malakoplakia is histologically characterized by the presence of Michaelis-Gutmann bodies in macrophages. Although not uncommon in the genito-urinary tract, isolated malakoplakia of the kidney is rarely found. Its main clinical presentation associates acute renal failure and acute pyelonephritis. The clue for diagnosis of renal malakoplakia is based on renal biopsy showing Michaelis-Gutmann bodies. Establishing the diagnosis of renal malakoplakia is essential as it determines the choice of antibiotics and duration of treatment. Prognosis remains poor, leading frequently to chronic renal failure. In this paper, we report four cases of renal malakoplakia and discuss clinical presentation, biological and pathological features, treatment and prognosis of this disease.
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