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  • Title: Coumarin-malonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular expression.
    Author: Kwon H, Lee K, Kim HJ.
    Journal: Chem Commun (Camb); 2011 Feb 14; 47(6):1773-5. PubMed ID: 21127785.
    Abstract:
    A nonfluorescent coumarin-malonitrile conjugate (1) was transformed into a strongly fluorescent molecule through the Michael addition of a thiol group to the α,β-unsaturated malonitrile of 1. The molecular probe has exhibited a highly selective fluorescence response toward biothiols (Cys, Hcy, GSH) with micromolar sensitivity both in vitro and in vivo.
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