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  • Title: SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model.
    Author: Wang Y, Liang Y, Vanhoutte PM.
    Journal: FEBS Lett; 2011 Apr 06; 585(7):986-94. PubMed ID: 21130086.
    Abstract:
    Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells.
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