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  • Title: Adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling by angiotensin II.
    Author: Egger M, Domenighetti AA.
    Journal: Trends Cardiovasc Med; 2010 Apr; 20(3):78-85. PubMed ID: 21130950.
    Abstract:
    Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling are not precisely known. We review this question, as well as acute Ang II-mediated modulation of ECC. In addition, we discuss adaptive/maladaptive modulation of cardiomyocyte ECC under chronic endogenous Ang II overproduction in the heart induced by local overexpression of the of the renin-angiotensin system in the mouse.
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