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  • Title: [Virilism due to an adrenal medullary tumor with ectopic ACTH syndrome (author's transl)].
    Author: Kley HK, Blessing MH, Nieschlag E, Wiegelmann W, Solbach HG, Krüskemper HL.
    Journal: Klin Wochenschr; 1975 Apr 01; 53(7):321-7. PubMed ID: 211312.
    Abstract:
    The case of a 14-year-old girl with hirsutism and virilism due to the secretion of ectopic ACTH by an adrenal medullary tumor is described. At the age of 5 years changes in appearance had begun with masculinization. The effect of ACTH-like material, measured by radioimmunoassay in plasma and in tumor tissue, was compensated partially by the hypothalamo-pituitary-adrenal feedback mechanism. Increased concentrations of dehydroepiandrosterone, estrone and testosterone in plasma and of 17-ketosteroids and free cortisol in urine originated in the adrenals. After operation of the tumor menarche began spontaneously, hirsutism disappeared and testosterone plasma concentrations returned to normal. An adrenogenital syndrome was excluded.
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