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Title: Efficient total synthesis of (-)-stemoamide. Author: Honda T, Matsukawa T, Takahashi K. Journal: Org Biomol Chem; 2011 Feb 07; 9(3):673-5. PubMed ID: 21132176. Abstract: An efficient diastereoselective synthesis of (-)-stemoamide has been accomplished from a pyroglutamic acid derivative in eight steps and with 24% overall yield. The synthesis features an intramolecular samarium diiodide-promoted 7-exo-trig cyclization of a ketyl radical generated from the corresponding aldehyde.[Abstract] [Full Text] [Related] [New Search]