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  • Title: DNA-templated covalent coupling of G4 PAMAM dendrimers.
    Author: Liu H, Tørring T, Dong M, Rosen CB, Besenbacher F, Gothelf KV.
    Journal: J Am Chem Soc; 2010 Dec 29; 132(51):18054-6. PubMed ID: 21133363.
    Abstract:
    Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and tetramers. Polymerization of the DNA-dendrimer conjugates was also demonstrated, as well as assembly in a circular structure on DNA origami and imaging by atomic force microscopy.
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