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  • Title: A successive clutter-rejection-based approach for early detection of diabetic retinopathy.
    Author: Ram K, Joshi GD, Sivaswamy J.
    Journal: IEEE Trans Biomed Eng; 2011 Mar; 58(3):664-73. PubMed ID: 21134810.
    Abstract:
    The presence of microaneurysms (MAs) is usually an early sign of diabetic retinopathy and their automatic detection from color retinal images is of clinical interest. In this paper, we present a new approach for automatic MA detection from digital color fundus images. We formulate MA detection as a problem of target detection from clutter, where the probability of occurrence of target is considerably smaller compared to the clutter. A successive rejection-based strategy is proposed to progressively lower the number of clutter responses. The processing stages are designed to reject specific classes of clutter while passing majority of true MAs, using a set of specialized features. The true positives that remain after the final rejector are assigned a score which is based on its similarity to a true MA. Results of extensive evaluation of the proposed approach on three different retinal image datasets are reported, and used to highlight the promise in the presented strategy.
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