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Title: Evidence for increased degeneration of mitochondria in old rats. A brief note. Author: Murfitt RR, Rao Sanadi D. Journal: Mech Ageing Dev; 1978 Sep; 8(3):197-201. PubMed ID: 211355. Abstract: An isotonic density gradient technique for separating mitochondria into two major components was applied to mitochondria isolated from young and old rats. Respiratory measuremtns indicate that the depression of state 3 respiration rates observed in the mitochondria from old rats when glutamate--malate is used as a substrate is due primarily to the faster sedimenting mitochondrial component.[Abstract] [Full Text] [Related] [New Search]