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  • Title: Effects of copper on the tyrosinase of liver pigment cells from Rana esculenta L.
    Author: Cicero R, Gallone A, Maida I, Pintucci G.
    Journal: Comp Biochem Physiol B; 1990; 96(2):393-7. PubMed ID: 2113847.
    Abstract:
    1. The liver pigment cells of R. esculenta L. constitute a peculiar pigment cell system of histiocytic nature and contain a tyrosinase-like activity localized in the protein component of melanosomes. 2. The effects of addition and/or removal of Cu on the DOPA-oxidase activity of the system were studied. 3. It was concluded that: (a) this tyrosinase behaves as a Cu-enzyme; (b) Cu could be involved in the regulation of the enzyme activity; and (c) mixtures of apoenzyme and active enzyme coexist in the melanosomes.
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