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  • Title: Neuroendocrinological effects of L-threo-3, 4-dihydroxyphenylserine (DOPS), a putative norepinephrine precursor, on healthy volunteers.
    Author: Semba J, Nankai M, Okubo Y, Kato M, Matsuura M, Takahashi R.
    Journal: Jpn J Psychiatry Neurol; 1990 Mar; 44(1):73-8. PubMed ID: 2113967.
    Abstract:
    The effect of L-threo-3, 4-dihydroxyphenylserine (DOPS) on plasma cortisol, prolactin, thyrotropin-stimulating hormone (TSH) and growth hormone concentrations was studied in nine healthy male volunteers. The drug was administered orally (300 mg or 600 mg DOPS) using a multiple crossover placebo-controlled study design. Plasma hormone concentrations were measured at 30 minute intervals for 3 hours after dosing. Plasma DOPS peak concentrations were observed between 2 and 3 hours after dosing. DOPS, however, had no effect on plasma hormone concentrations and this may be attributed to the known low brain permeability of DOPS in healthy subjects.
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