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  • Title: [Effects of gypsum on the firing of pyrogen-treated thermosensitive neurons in PO/AH of cats].
    Author: Wang Y, Yang Y, Bai X, Sun LH, Wu YH, Yang CL.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2008 Aug; 24(3):320-3. PubMed ID: 21141593.
    Abstract:
    AIM: To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum. METHODS: Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus(PO/AH) region was recorded by using extracellular microelectrode technique. RESULTS: The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum. CONCLUSION: The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.
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