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  • Title: Domino N-H/C-H bond activation: copper-catalyzed synthesis of nitrogen-bridgehead heterocycles using azoles and 1,4-dihalo-1,3-dienes.
    Author: Liao Q, Zhang L, Li S, Xi C.
    Journal: Org Lett; 2011 Jan 21; 13(2):228-31. PubMed ID: 21141932.
    Abstract:
    Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N-H bond and its adjacent C-H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.
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