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  • Title: Synthesis and antitumor activity of ureas containing pyrimidinyl group.
    Author: Jin C, Liang YJ, He H, Fu L.
    Journal: Eur J Med Chem; 2011 Jan; 46(1):429-32. PubMed ID: 21144621.
    Abstract:
    A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be critical for their biological activities.
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