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  • Title: Antibiotic prophylaxis in the placement of totally implanted central venous access ports.
    Author: Scaife CL, Gross ME, Mone MC, Hansen HJ, Litz CL, Nelson ET, Anderson CJ, Wagner G, Gawlick U, Nelson EW.
    Journal: Am J Surg; 2010 Dec; 200(6):719-22; disussion 722-3. PubMed ID: 21146010.
    Abstract:
    BACKGROUND: Antibiotic prophylaxis during placement of implanted central venous access ports (CVAP) has not been studied. This retrospective review compared the rate of catheter-related infections (CRIs) with and without perioperative antibiotics. METHODS: This was a single-center study that compared patients treated with and without a single dose of antibiotics during CVAP placement. CRIs were defined as a patient treated with antibiotics for port site induration, positive blood cultures, or suspicion of infection that led to port removal within 30 days of placement. RESULTS: CVAP were placed in 459 patients, 103 of whom (22.4%) received antibiotic prophylaxis. Surgical technique and patient demographics were similar to those patients not receiving antibiotics (356). All 9 (2%) CRIs occurred in the non-prophylactic antibiotic group (P = .218), with 5 infections resulting in port removal. CONCLUSIONS: Single-dose perioperative antibiotics may decrease CVAP infection rates and should be studied further in a prospective randomized trial.
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